ALLERGY AND ITS IMPACTS: HAS AYURVEDA BROADER VIEW TREATING CHRONIC ALLERGY OR EARLIER IN TREATING MAY LEAD TO GOODNESS OF ARTERIES, VEINS AND NORMAL FUNCTIONING OF TOTAL ORGANS ? SO IN ALLERGIC CONDITIONS , NARROWING OF ARTERIES, OBSTRUCTIVE PATHOLOGY, GANGRENE AYURVEDA TEND TO MODIFY PATHOLOGY CAUSING DISEASES. :

By Allergies millions of people suffer from Cardiovascular Disease. There are  various causes of allergies.With pollen (hay fever) being the most common trigger. Strong allergies are well known to weaken the immune system and the lungs. Many know,that allergies may also have a chronic impact on the heart and the cardiovascular system.   In certain situations, the immune system reacts particularly strongly to a pathogen with symptoms of varying intensities, which can trigger an inflammatory process. These substances are known as allergens. It is important to identify the allergens in each individual; to effectively treat the causative allergy and to prevent possible side effects.With the help of blood tests, immunoglobulin-E antibodies (IgE antibodies) can be detected in the blood to help draw  certain conclusions about the specific triggering allergen. Allergies can provoke symptoms that vary greatly from person to person, according to *"prakruthi"*; that are also often symptoms of other diseases. Known allergic factors can only  be treated  by  avoiding such items. Common  symptoms can vary as greatly as the allergens themselves: Coughing, Runny nose, Swelling and redness of the mucous membranes, fever, skin reaction, itching, tingling, burning eyes, Allergic Asthma,gastrointestinal complaints,                             The length of the reactions may vary. In certain situations, this can lead to anaphylactic shock, which must be treated immediately. Anaphylactic shock is an acute pathologic reaction of the immune system.One of the most well-known allergies is hay fever. This is an allergic inflammation of the nasal mucosa (rhinitis), that can be triggered by pollen and is therefore also known as a pollen allergy. Signs of hay fever include watery eyes, a congested nose or difficulty breathing. This type of allergy occurs seasonally, particularly in the spring and summer months, but can also continue into fall.With allergies that impact the airway, a chronic train reaction can be triggered. Allergies are a well-known trigger for asthma. When the mucous membranes are inflamed over a longer period of time, an allergy can also predispose one to bronchitis. Chronic lung disease may lead to Cor pulmonale, or right ventricular enlargement and failure, caused by lung disease.However, it should be determined if an allergy is the cause and if therapeutic measures can be taken to prevent unnecessary burden on the heart and the immune system. In addition to pollen, other allergies can also affect the cardiovascular system. The combination of physical stress and a weakened immune system leads to a weakening of the heart muscle and can develop into a heart muscle inflammation.To strengthen the heart, it is important to exercise frequently. Mild endurance sports should be performed in order to expand the bronchi and to improve the body’s oxygen supply, therefore strengthening the function of the heart.Allergies and Cardiovascular Disease, new studies suggests millions people suffer from allergies. There are just  various causes of allergies, with pollen (hay fever) being the most common trigger. Strong allergies are well known to weaken the immune system and the lungs. Circulating T cells contact blood vessels either when they extravasate across the walls of microvessels into inflamed tissues or when they enter into the walls of larger vessels in inflammatory diseases such as atherosclerosis. The blood vessel wall is largely composed of three cell types: endothelial cells lining the entire vascular tree, pericytes supporting the endothelium of microvessels and smooth muscle cells forming the bulk of large vessel walls. Each of these cell types interacts with and alters the behavior of infiltrating T cells in different ways, making these cells active participants in the processes of immune-mediated inflammation. In this review we have to consider, many narrowing of arteries.Vascular Cells as Participants in Immune Responses: Immune-mediated inflammation of peripheral tissues depends upon local recruitment of circulating leukocytes into an extravascular site. In most instances, leukocytes are recruited across the wall of post-capillary venules, which are composed of a continuous, one cell thick inner lining of endothelial cells (ECs) supported by an incomplete outer layer of pericytes (PCs) located within the basement membrane to which the ECs are attached. Larger vessels are not directly involved in leukocyte trafficking into tissues, but may themselves be a target of inflammation, when arteries become involved by cell-mediated immune responses as occurs in atherosclerosis. In the arterial wall, the EC lining of the vessel is completely covered by vascular smooth muscle cells (SMCs), some of which are located within the vessel intima, consisting of the EC lining and the anatomic space immediately beneath the basement membrane of the ECs. However, most SMCs are densely concentrated in a multilayered, circumferentially oriented array within the vessel media, which surrounds and is separated from the intima by the internal elastic lamina. The arterial adventitia is external to the media and separated from it by the external elastic lamina. The adventitia contains fibroblasts, nerve endings, microvessels (known as vasa vasorum) and vascular stem cells. Some mononuclear leukocytes may also be present in each of these compartments that can increase dramatically in number with inflammation.While much of this emphasis has been on the roles played by parenchymal cells in peripheral tissues, cells of the blood vessel wall are also positioned to affect lymphocytes and  blood vascular ECs, PCs and SMCs interact with infiltrating T cells in adaptive immune responses that occur near microvessels of inflamed peripheral tissues and within the wall of inflamed macrovessels. In this review we have to  consider how these interactions impact the nature of the immune response, with focus on observations made with human cells and tissues as said in Ayurveda. While each vascular cell type displays specific characteristics that define it as an EC, PC or SMC, each of these populations may vary significantly in both phenotype and function depending on the anatomic location; i.e. their most defining feature is simply their anatomic position within the vessel wall. Heterogeneity among vascular cells arises from several causes.Additionally, major species differences in vascular cell immunological functions have led to much confusion. 

Conditions that can cause this skin inflammation include:medications, infections

cancer, any substance that you might have an allergic reaction to.Most hypersensitivity vasculitis is caused by drug reaction. It can also occur alongside certain infections or viruses. 

Triggers for a hypersensitivity vasculitis reaction:

Hypersensitivity vasculitis is commonly triggered by a reaction to a drug. Common drugs linked to hypersensitivity vasculitis include:Certain antibiotics such as penicillin and sulfa drugs, some blood pressure medications, phenytoin (Dilantin, an antiseizure medication), allopurinol (used for gout)

Chronic bacterial infections or viruses can also cause this type of vasculitis. These include HIV, hepatitis B, and hepatitis C. People with autoimmune disorders such as lupus, rheumatoid arthritis, Sjogren’s syndrome, and inflammatory bowel disease can also experience this condition. It can also affect individuals with cancer.

Recognizing the symptoms of hypersensitivity vasculitis:The word “vasculitis” relates to blood vessel inflammation and damage. This inflammation and damage causes palpable purpura, the main sign of vasculitis.These spots may appear purple or red.  most likely find them on legs, buttocks, and torso.  might also develop blisters or hives on skin. Hives are potentially itchy bumps that appear on the skin as a result of an allergic reaction.Less common symptoms and signs  might experience include:joint pain, enlarged lymph nodes (glands that help remove bacteria from the bloodstream), kidney inflammation (in rare cases), mild fever.

When drug interaction is the cause, symptoms typically appear within seven to 10 days of exposure. Some people may experience symptoms as early as two days after taking certain medications.

How is it diagnosed?

A traditional way of diagnosing hypersensitivity vasculitis is determining whether you meet at least three of the five following criteria:older than 16 years of age skin rash with palpable purpura.skin rash that is maculopapular (contains both flat and raised spots), used a drug before developing a skin rash.  A biopsy of your skin rash showing that have white blood cells surrounding your blood vessels.However, not all experts agree that these are the only criteria necessary to consider when diagnosing this condition. Half of the time organs such as the kidneys, gastrointestinal tract, lungs, heart, and nervous system can also be involved, by evaluating  symptoms and ask about drug, medication, and infection history

Reviewing medical history and performing a physical exam, by taking a tissue sample, or biopsy, of rash,  the sample to a lab where it will be analyzed for evidence of inflammation surrounding blood vessels.Variety of blood tests, such as a complete blood count, kidney and liver function tests, and an erythrocyte sedimentation rate (ESR) to measure the degree of whole-body inflammation. Diagnosis and treatment will depend on the cause of your vasculitis and whether infection or inflammation of other organs is present.It is said  no cure for hypersensitivity vasculitis itself. The main goal of treatment will be to relieve your symptoms. In mild cases, no specific treatment is required.The medications that are taking. This information can help determine the potential cause for vasculitis. If  problem is traced back to a medication that  are currently taking, will probably advise  to stop taking it. However, shouldn’t stop taking any medications without your doctor’s recommendation. Symptoms should go away within several weeks of stopping the drugs. Ayurveda has explained proper digestion, excretion of food and others.The path of absorption and process of disease is well explained. The process of disease process, drugs acting on different level of tissues or dhathu's.Different kinds of approach in treatment. Natural medicines with special action of drugs in total relieving or curing symptoms in total. Considering body and environment treatment is taken up. Allergies leading to narrowing of arteries, veins causing  failure in body systems can be treated in Ayurveda way of treatment. We have to think and act in all the ways for mankind. 

CONSULTATIONS CONTACT:+916362583334 ,        919972831762 ,                                                  Dr. Ramachandra B H                                      BAMS(Bachelor in Ayurveda medicine & surgery),BAMS(Emergency Allopathic medicine ),PGDYS (Post Graduate Diploma in Yogic Science ) Former District Ayush officer .